GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BLCA | cis | rs9457247 | 1 | rs448060 | chr6:167382622 | RNASET2 | chr6:167343008-167412795:- | -0.23 | -4.95 | 1.14E-6 | Crohn's disease |
| BLCA | cis | rs9876781 | 1 | rs4490383 | chr3:48484683 | TREX1 | chr3:48501186-48509043:+ | -0.19 | -3.82 | 0.000153 | Longevity |
| BLCA | cis | rs9475752 | 1 | rs4490669 | chr6:56789465 | BEND6 | chr6:56819773-56892138:+ | -0.28 | -4.11 | 4.75E-5 | Menarche (age at onset) |
| BLCA | cis | rs60843830 | 1 | rs4497901 | chr2:239969 | SH3YL1 | chr2:218138-264810:- | -0.43 | -11.33 | 7.28E-26 | Spherical equivalent (joint main effects and education interaction) |
| BLCA | cis | rs10935120 | 1 | rs4498009 | chr3:134198008 | ANAPC13 | chr3:134196547-134204865:- | 0.51 | 8.23 | 2.91E-15 | Height |
| BLCA | cis | rs10935120 | 1 | rs4498009 | chr3:134198008 | CEP63 | chr3:134204575-134293852:+ | 0.26 | 4.44 | 1.16E-5 | Height |
| BLCA | cis | rs2243480 | 1 | rs451396 | chr7:65484074 | CCT6P1 | chr7:65216092-65228661:+ | 0.31 | 4.42 | 1.31E-5 | Diabetic kidney disease |
| BLCA | cis | rs12608504 | 1 | rs4531856 | chr19:18388383 | KIAA1683 | chr19:18367906-18385319:- | -0.23 | -4.21 | 3.22E-5 | Waist-to-hip ratio adjusted for body mass index |
| BLCA | cis | rs10935120 | 1 | rs4535272 | chr3:134299916 | ANAPC13 | chr3:134196547-134204865:- | -0.49 | -7.77 | 7.07E-14 | Height |
| BLCA | cis | rs10935120 | 1 | rs4535272 | chr3:134299916 | CEP63 | chr3:134204575-134293852:+ | -0.23 | -3.99 | 7.78E-5 | Height |
| BLCA | cis | rs454422 | 1 | rs454422 | chr20:5943693 | MCM8 | chr20:5931298-5975829:+ | -0.21 | -4.43 | 1.26E-5 | HIV-1 viral setpoint |
| BLCA | cis | rs2275426 | 1 | rs4545281 | chr1:46360054 | CCDC163P | chr1:45960581-45965646:- | -0.36 | -6.74 | 6.01E-11 | Body mass index |
| BLCA | cis | rs2243480 | 1 | rs4548056 | chr7:65298873 | CCT6P1 | chr7:65216092-65228661:+ | 0.31 | 4.37 | 1.63E-5 | Diabetic kidney disease |
| BLCA | cis | rs4372836 | 1 | rs4549034 | chr2:28972579 | TRMT61B | chr2:29072690-29093175:- | -0.29 | -5.1 | 5.37E-7 | Body mass index |
| BLCA | cis | rs11723261 | 1 | rs4549329 | chr4:239785 | ZNF718 | chr4:53272-156488:+ | 0.31 | 4.3 | 2.16E-5 | Immune response to smallpox vaccine (IL-6) |